Extended Data Fig. 9: Spatial chromatin accessibility mapping of human hippocampus. | Nature

Extended Data Fig. 9: Spatial chromatin accessibility mapping of human hippocampus.

From: Spatial profiling of chromatin accessibility in mouse and human tissues

Extended Data Fig. 9: Spatial chromatin accessibility mapping of human hippocampus.

a, Nissl-stained tissue section adjacent to the one used for spatial chromatin accessibility mapping and region of interest for spatial-ATAC-seq (50 µm pixel size). b, Unsupervised clustering analysis and spatial distribution of each cluster. For better visualization, we scaled the size of the pixels. c, Integration of scATAC-seq31 from human hippocampus and spatial-ATAC-seq. Colouring of spatial-ATAC-seq is consistent with (b). d, Co-embedding spatial-ATAC-seq and scATAC-seq datasets, coloured by gene score for the annotated lineage-defining gene31.

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