Table 1 Association of the DOCK2 variant with COVID-19 risk in the Japanese population
From: DOCK2 is involved in the host genetics and biology of severe COVID-19
rsID Chromosome position Cytoband allele Gene | Case collection period | Age | Phenotype | No. of subjects | Risk allele frequency (A) | Odds ratio (95% confidence interval) | P value | ||
|---|---|---|---|---|---|---|---|---|---|
Cases | Controls | Cases | Controls | ||||||
rs60200309 5:169519612 5q35 G/A DOCK2 | GWAS (April 2020 to January 2021) | All ages | COVID-19 vs control | 2,393 | 3,289 | 0.12 | 0.10 | 1.24 (1.09–1.41) | 0.0011 |
Severe COVID-19 vs control | 990 | 3,289 | 0.13 | 0.10 | 1.39 (1.16–1.66) | 3.1 × 10−4 | |||
<65 years | COVID-19 vs control | 1,484 | 2,377 | 0.12 | 0.10 | 1.32 (1.13–1.55) | 5.1 × 10−4 | ||
Severe COVID-19 vs control | 440 | 2,377 | 0.16 | 0.10 | 2.01 (1.58–2.55) | 1.2 × 10−8 | |||
Replication (February 2021 to September 2021) | All ages | Severe COVID-19 vs control | 1,243 | 3,769 | 0.11 | 0.11 | 1.00 (0.85–1.19) | 0.96 | |
<65 years | 833 | 1,242 | 0.12 | 0.10 | 1.28 (1.02–1.61) | 0.033 | |||
