Extended Data Fig. 8: Model predicted time courses of responses to JNK and RSK inhibitors.

Experimental data are imposed on model predicted time-courses of signaling responses of TrkA (blue) and TrkB (red) cells treated with (A) JNK inhibitor (1 μM) or (B) RSK inhibitor (1 μM) and stimulated with 100 ng/ml NGF and BDNF, respectively. Dashed lines show the time courses in the absence of inhibitor. TrkA, blue; TrkB, red. Data are presented as mean values +/− SEM for n = 3 biologically independent experiments.