Extended Data Fig. 1: Mutations and copy number losses targeting the same genes are mutually exclusive in G3 and G4 MB.
From: Failure of human rhombic lip differentiation underlies medulloblastoma formation
a, b, c, Oncoprint summarizing gene mutations and copy number losses in their corresponding genomic loci (chromosome arm) for CHD (a), FANC (b) and ELP (c) driver families. Mutations are less frequent than copy number losses but tend to occur independently suggesting they are targets of the deletions. d, Mutual exclusivity of mutation and copy number loss events targeting genes in the CHD, FANC, and ELP families. e, Overlap between events targeting CHD, FANC, or ELP genes. Most G4 MB tumours are haploinsufficient for genes in at least two families through a single deletion event.
