Extended Data Fig. 2: Clustering of G4 MB driver genes in the human genome predisposes humans to develop MB.

a, Cartoon of the Homo sapiens genome with the locations of known and newly identified G3 and G4 MB candidate driver genes demonstrating clustering of genes at locations known to be deleted in G3 and G4 MB. b, Frequency of whole chromosome arm loss is significantly correlated with the number of driver gene families—as detailed in (a)—contained on the arm. Significance was assessed by a two-sided linear regression model; grey shaded area denotes the 95% confidence interval. c, Mutual exclusivity of copy number losses of chromosome arms 17p, 16q, and 8q. Significance was assessed using the impurity test for mutual exclusivity, implemented in the R package DISCOVER⁴¹.