Extended Data Fig. 9: RNAseq analysis of tumoral NK cells from KPC tumour-bearing mice under mono or dual therapy of cGAMP+anti-IL-35.
From: STING-induced regulatory B cells compromise NK function in cancer immunity
a, GSEA analysis of RNAseq of tumoral NK cells. Normalized Enrichment Score (NES) plot of top 20 hallmark signature gene sets enriched in combination cGAMP+anti-IL-35 vs. Ctrl treated NK cells. b, GSEA showing the enrichment of “interferon alpha response” in tumoral NK cells isolated from mice treated with cGAMP+anti-IL-35 vs. Ctrl NK cells as noted in (a). c, Heatmap of “mitotic spindle pathway” genes in NK cells isolated from animals treated with cGAMP+anti-IL-35 vs untreated Ctrl NK cells. d, Venn diagram showing down-regulated DEGs in combination cGAMP+anti-IL-35, cGAMP or anti-IL-35 vs. Ctrl groups.
