Extended Data Fig. 8: PD-1 + IL-2 combination therapy results in a more favourable CD8⁺ effector/CD4⁺ Treg ratio compared to IL-2 monotherapy.

Mice chronically infected with were either left untreated, or treated with anti-PD-L1 antibody alone, IL-2 therapy alone, or combination therapy. a, Numbers of FOXP3⁺ CD4⁺ regulatory T cells (Tregs) in the indicated tissues. b, Numbers of LCMV-specific (D^bGP33⁺ and D^bGP276⁺) CD8⁺ T cells. c, Ratio of LCMV-specific (D^bGP33⁺ and D^bGP276⁺) CD8⁺ T cells vs. FOXP3⁺ CD4⁺ T cells (CD8⁺ effector/CD4⁺ Treg ratio). d, Correlation between viral titre and CD8⁺ effector/CD4⁺ Treg ratio in the various tissues. Results were pooled from 5-8 experiments with n = 2-4 per group in each experiment. Data are presented as geometric mean and 95% CI (a, b), mean and SEM (c), or linear regression line and Pearson correlation coefficient (two-tailed) (d) with p values. Statistical comparisons were performed using Kruskal-Wallis test with Dunn’s multiple-comparison test (a–c). Untx, untreated.

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