Extended Data Fig. 9: Rescue of neuronal electrophysiological phenotypes in MIA offspring using prenatal microglia replacement related to Fig. 5.
From: Prenatal immune stress blunts microglia reactivity, impairing neurocircuitry
a, Two-sample KS test for the cumulative distribution of the inter-event intervals of the sEPSC frequency from Tom+ (D1R) in Fig. 5c. nCon:D1R=11 cells from 8 animals from 5 litters, nMIA:D1R=10 cells from 4 animals from 3 litters. b, sEPSC amplitude of Tom+ (D1R) and Tom- (D2R) medium spiny neurons (MSNs) in Fig. 5c. n are individual cells. Data are shown as mean ± s.e.m and analysed using t-tests. nCON:D1R=11 cells from 8 animals from 5 litters, nMIA:D1R=10 cells from 4 animals from 3 litters, nCON:D2R = 10 cells from 6 animals from 4 litters, nMIA:D2R=13 cells from 6 animals from 4 litters. c, Spine density of striatal MSNs in the ventral Str. n are individual animals. Data are shown as mean ± s.e.m and analysed using a t-test. nCon = 6, mice from 3 litters from 28 cells, nMIA = 7 mice from 3 litters from 34 cells. d, mESPC amplitudes of Tom- (D2R) MSNs analysed in Fig. 5e. n are individual cells. Data are shown as mean ± s.e.m and analysed using a t-test. nCON:D2R=16 cells from 3 animals from 2 litters, nMIA:D2R=12 cells from 3 animals from 2 litters.
