Fig. 1: Relationship between frequency and estimated effect sizes of minor alleles.
From: A saturated map of common genetic variants associated with human height
Each dot represents one of the 12,111 quasi-independent GWS SNPs that were identified in our cross-ancestry GWAS meta-analysis. Data underlying this figure are available in Supplementary Table 10. SNP effect estimates (y axis) are expressed in height standard deviation (s.d.) per minor allele as defined in our cross-ancestry GWAS meta-analysis. SNPs were stratified in five classes according to their P value (P) of association. We show two curves representing the theoretical relationship between frequency and expected magnitude of SNP effect detectable at P < 5 × 10−8 with a statistical power of 90%. Statistical power was assessed under two experimental designs with sample sizes equal to n = 0.5 million and n = 5 million.
