Fig. 2: Brisbane plot showing the genomic density of independent genetic associations with height.
From: A saturated map of common genetic variants associated with human height
Each dot represents one of the 12,111 quasi-independent GWS (P < 5 × 10−8) height-associated SNPs identified using approximate COJO analyses of our cross-ancestry GWAS meta-analysis. Data underlying this figure are available in Supplementary Table 10. GWS SNPs with the largest density on each chromosome were annotated with the closest gene. We highlight 24 of 12,111 associations that are mainly contributed by groups of non-European ancestry (3 from African ancestries, 10 from Hispanic ethnicities or ancestries and 11 from East Asian ancestries). The full list of height-associated SNPs detected in groups of non-European ancestry and independent of associations detected in European ancestry GWASs is reported in Supplementary Table 9. Signal density was calculated for each associated SNP as the number of other independent associations within 100 kb. A density of 1 means that a GWS COJO SNP shares its location with another independent GWS COJO SNP within less than 100 kb. The mean signal density across the genome is 2 and the median signal density is 1 (s.e. 0.14 and 0.0, respectively). The s.e. values were calculated using a leave-one-chromosome-out jackknife approach (LOCO-S.E.). SNPs that did not reach genome-wide significance are not represented on the figure.
