Extended Data Fig. 3: Replication of marginal associations in the EBB.
From: A saturated map of common genetic variants associated with human height
a, Each dot represents one the 12,111 SNPs detected in our trans-ancestry meta-analysis. The x-axis represents the expected statistical power to replicate each association (P<0.05/9,473 = 5.3×10−6; where 9,473 is the number of associations reaching marginal genome-wide significance in our discovery trans-ancestry GWAS and with a minor allele frequency>1% in the EBB sample). The y-axis represents the -log10 of the association p-value in the EBB multiplied by the product of signs of estimated SNP effects in the discovery and in the EBB. Horizontal dotted line represents replication at P<0.001 and the vertical dotted line indicates 80% of statistical power. SNPs highlighted in green have an expected statistical power for replication >80%. One outlier (rs11100870), highlighted in red, does not replicate in the EBB sample. b, Proportion (P) of SNPs with a sign-consistent estimated effect between discovery GWAS (N~5.3M) and EBB. Expected proportions (E[P]) are calculated using equation (2) in the Methods. Error bars are defined as 1.96×\(\sqrt{P(1-P)/m}\), where m is the number of SNPs in the corresponding MAF interval.
