Table 2 Overview of five European-ancestry GWASs re-analysed in our study to quantify the relationship between sample size and discovery

From: A saturated map of common genetic variants associated with human height

Down-sampled GWAS

Max n (mean n)

Number of GWS COJO SNPs

Percentage of the genome covered by GWS loci (35 kb) (%)

Lango Allen et al. (2010)19a

130,010 (128,942)

240

0.5

Wood et al. (2014)20

241,724 (239,227)

633

1.4

Yengo et al. (2018)3

695,648 (688,927)

2,794

5.8

GIANT-EUR (no 23andMe)

1,632,839 (1,502,499)

4,867

9.7

23andMe-EUR

2,502,262 (2,498,336)

7,020

13.6

  1. Summary statistics from the three published GWASs were imputed using the ImpG-Summary software to maximize the coverage of HM3 SNPs (Methods). GWS loci are defined as in the legend of Table 1.
  2. aSummary statistics from the Lango Allen et al. study19, initially over-corrected for population stratification using a double genomic control correction, were re-inflated such that the LD score regression intercept estimated from re-inflated test statistics equals 1.
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