Extended Data Fig. 3: Chemistry and Mass-spectrometry analyses of the modified histones. | Nature

Extended Data Fig. 3: Chemistry and Mass-spectrometry analyses of the modified histones.

From: Structure of the NuA4 acetyltransferase complex bound to the nucleosome

Extended Data Fig. 3

(a) Schematic diagram of the chemical semi-synthesis of histone H4 with CMC modification at Lys16. (b) Mass-spectrometry identification of the CMC-modified H4 (the expected mass is 11092.57 Da). (c) Mass-spectrometry identification of the H3KC36me3-modified H3 (the expected mass is 15299.76 Da).

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