Extended Data Fig. 7: The locations of key mutations mapped onto the TMC-1 complex.
From: Structures of the TMC-1 complex illuminate mechanosensory transduction
a, The locations of cysteine mutations that perturb TMC-1 single channel conductance in mice are shown on the C. elegans TMC-1 complex. The C. elegans residue number is labeled and the corresponding mouse residue is indicated in parentheses. b, The structure of the TMC-1 complex and the locations of mutations associated with hearing loss or deafness. Cα positions of the residues in question are shown as yellow (TMC-1), purple (CALM-1), or blue (TMIE) spheres. c, A table of the residues shown in panel b. Mutations linked to hearing loss and deafness in humans are colored black and blue, respectively.
