Extended Data Fig. 6: Comparison of the Lewy fold with structures of α-synuclein filaments from human brains or assembled from recombinant proteins.
From: Structures of α-synuclein filaments from human brains with Lewy pathology
(a), Ribbon plot of the Lewy fold; the protein chain is coloured as in Fig. 2. Highlighted by red, orange, yellow, green, blue and purple areas are substructures that are individually shared with other filament structures. These local similarities are indicated with the same coloured areas and the overlays of the corresponding substructures are shown in sticks on the following panels (b-f). (b), Common core structure of MSA Type I and Type II filaments (made of PFIA/IIA 14–47 and PFIB/IIB 41–99), with a shared substructure highlighted in yellow. (c), pY39 α-synuclein protofilament (PDB:6L1T) with two different substructures highlighted in orange and green. (d), N-terminally truncated α-synuclein (40–140) dimeric filament (PDB:7LC9), with two different substructures in its protofilaments, highlighted in blue and yellow. Residue numbers with apostrophes indicate those from the other protofilament. (e), Polymorph 2a filament (PDB:6SSX), with two substructures highlighted in purple and orange. (f), Polymorph 1a filament (PDB:6H6B) contains yellow-coloured substructures in its protofilaments and a red-coloured substructure in their dimeric interface.
