Extended Data Fig. 8: Fiber location for photometry recording and behavior encoding by the TS does not predict resilience in males.

a, Relationship between average time spent engaging in each behavior and kernel weight for NAc(DAT::GCaMP6f) encoded by corresponding behavioral events (2-sided pearson correlation, *p < 0.05, N = 19 males, purple designating resilient animals, green showing susceptible, see Supplementary Table 1 for statistical values). b, Anatomical locations of photometry fiber tips targeted to the nucleus accumbens (NAc) and tail of the striatum (TS), overlaid on regions defined by the Paxinos Atlas (scale bar 1mm, Paxinos splits TS into subregions of the caudal caudoputamen). Animals omitted on the basis of poor signal shown in red, or omitted on the basis of poor targeting shown in magenta, included animals shown in black. c, Lack of relationship between location of recording fiber tips and SI time. d, Average kernel weights for behaviors encoding NAc(DAT::GCaMP6f) in mice grouped by fiber location in the NAc (p-values shown for 2-sided t-test for difference in means in average activity from 0.5 to 1.5s following the behavior event, see Supplementary Table 1 for statistical values). e, Average kernel weights for behaviors encoding TS(DAT::GCaMP6f) in mice grouped by susceptibility (p-values shown for 2-sided t-test for difference in means in average activity from 0.5 to 1.5s following the behavior event, N = 7 susceptible (green) and 12 resilient (purple) mice, see Supplementary Table 1 for statistical values). Across panels, *p < 0.05, **p < 0.01.