Extended Data Fig. 8: The impact of APOE genotype on COVID-19 outcome is not confounded by population structure or its impact on longevity.
From: Common human genetic variants of APOE impact murine COVID-19 mortality
a, Multivariate analysis of the impact of age, sex, the first ten genetic principal components, and APOE genotype on survival of patients with SARS-CoV-2 infection in the UK Biobank (P values according to multivariable Cox proportional hazards model, n = 13,207). b–c, Dot plot of the genetic principal components 1-2 (b) and 3-4 (c) colored by APOE genotype of SARS-CoV-2-positive patients of the UK Biobank. PC, principal component. d–e, Dot plot of the genetic principal components 1-2 (d) and 3-4 (e) colored by APOE genotype of SARS-CoV-2-positive patients with European ancestry in the UK Biobank. f, Multivariate analysis of the impact of age, sex, and APOE genotype on survival of patients with European ancestry and SARS-CoV-2 infection in the UK Biobank (P values according to multivariable Cox proportional hazards model, n = 10,333). g, Survival of patients from (f) stratified by APOE genotype (P value according to log-rank test). h, Survival of UK biobank participants over a 30 day observation period in January 2019. The start of the observation period was Jan 1, 2019, and data were censored on Jan 31, 2019 (P value according to log-rank test; n = 384,106). Error bars in a and f indicate 95% confidence intervals.
