Extended Data Fig. 2: Viral load early post infection and extended histopathologic analysis of lungs from SARS-CoV-2 MA10-infected APOE knock-in mice.
From: Common human genetic variants of APOE impact murine COVID-19 mortality
a, TaqMan qPCR for SARS-CoV-2 N1 in homogenized lungs from APOE knock-in mice on day 2 post infection with SARS-CoV-2 MA10 (data pooled from two experiments; P values according to one-tailed Mann-Whitney test; n = 12, 11, 11 for APOE2, APOE3, and APOE4, respectively; boxplot whiskers extend to the smallest and largest value within 1.5 × interquartile ranges of the hinges, and box centre and hinges indicate median and first and third quartiles, respectively). b–h, Histopathologic scoring of lungs from APOE knock-in mice on day 4 post infection with SARS-CoV-2 MA10 for hemorrhage (b), edema (c), mononuclear cell infiltrates (d), neutrophilic cell infiltrates (e), interstitial infiltrates (f), perivascular infiltrates (g), and endothelialitis/vascular changes (h); P values according to two-sided Mann Whitney-tests, n = 18, 22, 15 for APOE2, APOE3, and APOE4, respectively.
