Extended Data Fig. 10: pS366 of pSTING binds to a basic patch of AP-1σ. | Nature

Extended Data Fig. 10: pS366 of pSTING binds to a basic patch of AP-1σ.

From: Clathrin-associated AP-1 controls termination of STING signalling

Extended Data Fig. 10: pS366 of pSTING binds to a basic patch of AP-1σ.The alt text for this image may have been generated using AI.

a, Sequence alignment of AP-1σ in different species and human σ subunit isomers. b, Bio-layer interferometry binding studies of LBD-STING or pLBD-STING with AP-1 ΔμCTD σKR. c, HEK293T cells transfected with FLAG-tagged STINGWT and HA-tagged AP-1γWT, γR15E, σWT, σI103S or σV88D, respectively, were treated with 2.5 µM diABZI for 2 h, immunoprecipitated (IP) with anti-FLAG antibody and then analysed by western blot. One representative of two (b,c) independent experiments is shown.

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