Extended Data Fig. 1: EESREHAB restores walking in nine humans with chronic SCI.
a, Chronophotography of nine human participants with chronic SCI who are walking independently with EESON and the help of crutches or a front-wheel walker at the end of the neurorehabilitation period. b, Bar plots reporting the volitional modulation of the step for each participant during EESON (paired samples two-tailed t-tests: P9: n = 13 small and 12 large steps, t = 10.6, P = 2.3 × 10–10; P1: n = 13 small and 9 large steps, t = 6.4, P = 3.1 × 10–6; P6: n = 13 small and 10 large steps, t = 4.8, P = 9.9 × 10–6; P3: n = 32 small and 24 large steps, t = 23.0, P < 10–15; P4: n = 10 small and 7 large steps, t = 12.1, P < 10–15; P2: n = 15 small and 15 large steps, t = 3.0, P = 0.006; P8: n = 15 small and 10 large steps, t = 5.3, P = 2.0 × 10–5; P5: n = 12 small and 8 large steps, t = 3.0, P = 0.0073). c, Body schemes report the lower extremity motor score (LEMS) measured before EESREHAB and after EESREHAB. Relative changes in lower limb motor and sensory scores after EESREHAB are also reported. d, WISCIII score measured before EESREHAB and after EESREHAB with EESOFF and EESON. e, Bar plots reporting the outcome of the clinically standardized six-minute walk test and 10-meters walk test before EESREHAB, and after EESREHAB with EESOFF and EESON. Participants used a front-wheel walker for stability, but did not receive any external assistance. Two participants could not walk without assistance at the hip or at least 10 to 30% of body weight support for stability. Consequently, they did not perform these evaluations. Line plots report the evolution of the required amount of body weight support (% of bodyweight) necessary to enable each participant to walk independently over the period of EESREHAB. Bar plots show the mean with individual data points overlaid. Error bars show the standard error of the mean. *, P < 0.05; **, P < 0.01; ***, P < 0.001.
