Extended Data Fig. 6: Abortive hepatocytes show unique transcriptomic markers.
From: A spatiotemporally resolved single-cell atlas of the Plasmodium liver stage
a-d, smFISH validations of host genes up regulated in abortive hepatocytes at 40hpi. Top row – Abortive; Bottom row – Productive. Per pair of images: Left panel - Phalloidin (Phal) in red, parasite Ch12 18S rRNA (18Sp, PBANKA_1245821) in green, Dapi blue; Right panel – Cxcl10/Cdkn1a/Sqstm1/Hes1 mRNA in white. Dashed yellow line: infected hepatocyte. Images are representatives of 35/30/30/49 (Cxcl10/Cdkn1a/Sqstm1/Hes1) imaging fields from 2 mice.
