Fig. 2: SAM domain contacts within the TNKS2 SAM–PARP filament.
From: Structural basis of tankyrase activation by polymerization
a, Cryo-EM map and model showing three adjacent SAM–PARP protomers each from antiparallel protofilaments (D, E, F and N, O, P). Arrows indicate domain interactions, and letters refer to different SAM–PARP protomers (see Fig. 1c). b, Model of the TNKS2 PARP domain with buried surfaces identified by PISA21 highlighted in the respective colour code of the interacting domain (see Fig. 1c). Residues buried by two adjacent surfaces are shown in orange. c, Cartoon representation of SAM–SAM head-to-tail contacts (323 Å2), with key interacting residues shown in stick representation and bonds indicated by orange lines. EH, end helix; ML, mid-loop. d, As for c but for SAM–SAM interprotofilament contacts (161 Å2). e, As for c but for SAM/linker–PARP contacts (699 Å2).
