Extended Data Fig. 5: Schematic diagram of the potential source of enlarged LAMP1-positive vesicles through disruption of the endosomal-lysosomal-autophagic system.
From: PLD3 affects axonal spheroids and network defects in Alzheimer’s disease
The endosomal-lysosomal-autophagic system is a dynamic and interconnected network of membranous organelles and vesicles that involves multiple biological processes, including endocytosis, autophagy, organelle maturation, vesicle trafficking and degradation. Enlarged LAMP1-positive vesicles (ELPVs) likely represent vesicular organelles at different stages of maturation into lysosomes, including late endosomes/multivesicular bodies (MVBs), endolysosomes (fusion product between late endosomes/MVBs and lysosomes), amphisomes (fusion product between autophagosomes and late endosomes/MVBs) and autolysosomes (fusion product between autophagosomes and lysosomes).
