Extended Data Fig. 8: SPR sensorgram of AS TCRs and peptide-HLA-B*27:05. | Nature

Extended Data Fig. 8: SPR sensorgram of AS TCRs and peptide-HLA-B*27:05.

From: Autoimmunity-associated T cell receptors recognize HLA-B*27-bound peptides

Extended Data Fig. 8: SPR sensorgram of AS TCRs and peptide-HLA-B*27:05.The alternative text for this image may have been generated using AI.

(a-p) Binding analysis of AS TCRs AS3.1, AS4.1, AS4.2, AS4.3 and AS8.4 to GPER1/PRPF3/RNASEH2B/YEIH-HLA-B*27:05 molecules. Increasing concentrations of each TCR was injected over immobilized GPER1/PRPF3/RNASEH2B/YEIH-HLA-B*27:05 complexes. The response unit vs concentration plots were fitted to a steady state affinity model. The SPR measurements were performed once for each TCR-pMHC interaction.

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