Extended Data Fig. 9: Omit maps of AS TCR-peptide-HLA-B*27:05 complex contoured at 1 σ. | Nature

Extended Data Fig. 9: Omit maps of AS TCR-peptide-HLA-B*27:05 complex contoured at 1 σ.

From: Autoimmunity-associated T cell receptors recognize HLA-B*27-bound peptides

Extended Data Fig. 9: Omit maps of AS TCR-peptide-HLA-B*27:05 complex contoured at 1 σ.The alternative text for this image may have been generated using AI.

a. Simulated annealing composite omit map of the entire AS4.3 TCR-RNASEH2B-HLA-B*27:05 complex contoured at 1 σ. The TCRα chain is colored red; the TCRβ chain is colored yellow; the peptide is colored magenta; the β2M is colored cyan; the HLA-B*27:05 heavy chain is colored green. (b-h) Simulated annealing composite omit maps of the AS4.3 TCR-RNASEH2B-HLA-B*27:05, AS3.1 TCR-PRPF3-HLA-B*27:05, AS4.2 TCR-PRPF3-HLA-B*27:05, AS4.2 TCR-YEIH-HLA-B*27:05, AS4.3 TCR-PRPF3-HLA-B*27:05, AS4.3 TCR-YEIH-HLA-B*27:05 and AS8.4 TCR-YEIH-HLA-B*27:05 complex interfaces contoured at 1 σ. The TCR CDR1α is colored red; the TCR CDR3β is colored yellow; the peptide is colored magenta; the HLA-B*27:05 heavy chain is colored green.

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