Extended Data Fig. 1: Identification of rearrangements based on Hi-C data.

a, Pie chart showing all 4,543 rearrangements identified and which cell line or patient tumor sample they are derived from. The order in the pie chart starts with A172 cells and proceeds counter-clockwise. b, Resolution of structural variants calls from Hi-C. Calls are first identified at low resolution and then progressively refined. The resolution reported is the highest resolution with which a given structural variant is identified. c, Chromatin interaction maps from mixed lineage leukemia cell lines with known MLL/KMT2A rearrangements. The maps show the presence of translocations on chromosome 4 in MV4;11 cells (left), chromosome 6 in ML2 cells (middle), and chromosome 9 in MOLM13 cells (right). d, Heat maps showing known disease defining translocations from five Mantle Cell lymphoma cell lines (Rec-1, Mino, Maver, Jeko, Granta). e, Heat maps showing known disease defining translocations in two Chronic Lymphocytic Leukemia cell lines (K562 and KBM7).