Extended Data Fig. 8: The impact of exercise and the microbiome on sensory neuron activity.
From: A microbiome-dependent gut–brain pathway regulates motivation for exercise
a, Representative RNAScope images of dorsal root and nodose ganglia before and after exercise, with and without Abx treatment. b, Number of cFos+ cells in dorsal root ganglia before and after exercise. c, Proportion of cFos+ cells in dorsal root ganglia from exercised mice that are TRPV1+ and TRPV1−. d-g, Number of TRPV1+ (d, f) and cFos+ TRPV1+ (e, g) cells in the dorsal root ganglia (d, e) and nodose ganglia (f, g) in exercised Abx-treated mice and controls. h, i, Expression of Fos (h) and Homer1 (i) in the dorsal root ganglia of sedentary and post-exercise mice, with or without Abx treatment. Error bars indicate means ± SEM. * p < 0.05, ** p < 0.01, *** p < 0.001, **** p<0.0001. Exact n and p-values are presented in Supplementary Table 2.
