Extended Data Fig. 2: Cryo-EM densities and model of TMSs and dimeric assembly of NIS.
From: Structural insights into the mechanism of the sodium/iodide symporter
a. α-helical features are clearly visible in all 13 TMSs. b. NIS structure viewed from the extracellular side of the membrane, with the numbered TMs depicted as cylinders (left panel). NIS embedded in the membrane, top view; an example of 2D classes representing the corresponding view is shown in the black square (middle panel). NIS structure viewed from the intracellular side of the membrane, with the numbered TMs depicted as cylinders (right panel). c. Residues interacting at the dimer interface in apo-NIS.
