Extended Data Fig. 1: Maximum-likelihood phylogeny of Cas12a2 and Cas12a nucleases, with Cas12b as an outgroup.
From: Cas12a2 elicits abortive infection through RNA-triggered destruction of dsDNA
The phylogenetic tree generated using amino acid sequences is the annotated version of Fig. 1a. The shaded regions designate Cas12a2 (red), Cas12a (blue), and Cas12b (grey) orthologues. The blue and red filled circles indicate systems that contain both Cas12a2 and Cas12a. Transfer bootstrap expectation (TBE) values are shown at the nodes.
