Extended Data Fig. 8: UDCA plasma concentration in vivo.
From: FXR inhibition may protect from SARS-CoV-2 infection by reducing ACE2
(a) UDCA concentration in the plasma of hamsters over 7 days of treatment with 416 mg/kg/day of UDCA. N = 6 animals/group; line, median. (b) Viral titre showing levels of infectious virus as measured by plaque assay in lungs in directly inoculated hamsters and sentinel animals treated with UDCA or vehicle and co-housed with infected animals. Samples were collected after 4 days of co-housing. N = 6 UDCA vs n = 3 vehicle animals; Kruskal–Wallis test with Dunn’s correction for multiple comparisons. Animals from each experiment are represented with different symbols; line, median.
