Extended Data Fig. 1: Emergence of convergent mutations on SARS-CoV-2 RBD. | Nature

Extended Data Fig. 1: Emergence of convergent mutations on SARS-CoV-2 RBD.

From: Imprinted SARS-CoV-2 humoral immunity induces convergent Omicron RBD evolution

Extended Data Fig. 1: Emergence of convergent mutations on SARS-CoV-2 RBD.The alternative text for this image may have been generated using AI.

a, Number of independent Omicron sublineages that gained mutations on the corresponding SARS-CoV-2 RBD residue and exhibited growth advantage compared to its ancestral Omicron strain (BA.2, BA.2.75, or BA.5). Residues that were mutated in at least five independent sublineages are considered convergent (dash threshold). Recombinants were not counted, but their derivatives were included in the analysis (see Methods). b, Proportions of each convergent mutation in all detected Spike sequences. Spike sequences were from GISAID (Spike protein sequences released on Oct 27, 2022). The percentage of the wild-type residue is not plotted, except for 493Q, considering the prevalence of R493Q reversion. c, List of Pango lineages shown in Extended Data Fig. 1a.

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