Extended Data Fig. 10: Burden heritability enrichments of drug target gene sets.
From: Polygenic architecture of rare coding variation across 394,783 exomes
We used BHR to estimate the ultra-rare loss-of-function burden heritability enrichment in sets of manually curated drug target genes from a previous publication6. For all panels, error bars are standard errors, and bars are shaded in blue if the enrichment is significantly greater than 1. (A) Burden heritability enrichment in n = 14 blood pressure drug target genes (union of diastolic and systolic blood pressure gene sets from reference publication). (B) Burden heritability enrichment in n = 8 bone mineral density drug target genes. (C) Burden heritability enrichment in n = 6 calcium drug target genes. (D) Burden heritability enrichment in n = 10 lipid drug target genes (union of LDL and triglyceride gene sets from reference publication). (E) Burden heritability enrichment in n = 6 red blood cell drug target genes. (F) Burden heritability enrichment in n = 7 type 2 diabetes drug target genes.
