Extended Data Fig. 6: CellOracle TF KO simulation results for Paul et al. haematopoiesis data: part 2.
From: Dissecting cell identity via network inference and in silico gene perturbation
a–d, CellOracle KO simulation results for Gata2 (a), Runx1 (b), Fli1 (c) and Lmo2 (d). The simulated cell state transition vector field is visualized with perturbation scores (PS; magenta: negative score; green: positive score). The right column shows a summary of the TF role based on the CellOracle simulation results, cell transition vector, and PS. For example, a positive PS in the TF KO simulation (green) implies that the TF has a role in cell state maintenance or inhibiting cell differentiation. In contrast, a negative PS in the KO simulation (magenta) implies that the TF normally promotes cell differentiation.
