Extended Data Fig. 1: Rv-1928z and Rv-19BBz pre-infusion and in vivo CAR T cell phenotyping.
From: TET2 guards against unchecked BATF3-induced CAR T cell expansion
a,b, Pre-infusion transduction efficiency and phenotyping by flow cytometry of Rv-1928z (a) and Rv-19BBz (b) CAR T cells. c,d, Tumour monitoring of NALM6 bearing mice treated with Rv-1928z (c) and Rv-19BBz (d) CAR T cells. e,f, Bone marrow (e) and Splenic (f) CAR T cell quantification at 3 weeks post infusion. Data is represented as mean±SE [n = 5 (Rv-1928z), n = 6 (Rv-19BBz)]. g,h Differentiation phenotyping of pooled bone marrow CAR T cells at week 3 post infusion. Data from another experiment included in supplementary information. i, CAR T cell inhibitory receptor expression at week 3 post infusion from mouse bone marrow (n = 3). p values were determined by two-sided Mann–Whitney test (e,f) and two-sided χ2 test (h). p < 0.05 was considered statistically significant. p values are denoted: p > 0.05, not significant, NS; *, p < 0.05. Replicate information for g,i are available in Supplementary Table 3. Exact p values are available in Supplementary Table 4.
