Fig. 2: Comparison of different achiral and chiral Brønsted acids 3–6 in the formation and decomposition of isopiperitenol (2). | Nature

Fig. 2: Comparison of different achiral and chiral Brønsted acids 3–6 in the formation and decomposition of isopiperitenol (2).

From: Catalytic asymmetric synthesis of cannabinoids and menthol from neral

Fig. 2

a,b, Four different catalysts were used for 1H NMR reaction monitoring of the cyclization of neral (a) and the reaction of isopiperitenol to undesired side products (b) under optimized reaction conditions. d.r. and e.r. were determined by gas chromatography (GC) analysis. The shown decomposition products only represent the main side products characterized by 1H NMR spectroscopy.

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