Extended Data Fig. 1: Replicates of bleb inhibition viability experiments.
From: Blebs promote cell survival by assembling oncogenic signalling hubs
(A) Fraction of cell surface comprised of blebs for MV3 cells treated with different concentrations of WGA. Dashed lines separate quartiles. Dots represent individual cells. (B) Individual bleb inhibition viability experiments, as summarized in Fig. 1a. Each pairing of adhered/detached cell experiments was performed on the same day and seeded with cells from the same diluted cell suspensions. (C) Morphology of cells in “adhered” conditions, related to Fig. 1a. Cells grown without perturbation for 24 h on adherent chamber slides. Representative of either 688 (MV3), 405 (M498), or 576 (A375) cells observed. (D) Paired mean differences between control and experimental condition shown in Gardner-Altman estimation plots for the data presented in Figs. 1d, 3b, 4d, 4e, and 4f. Gray distributions represent 5000 bootstrapped samples, black bars represent 95% confidence intervals, black dots represent mean difference.
