Extended Data Fig. 4: Characterization of T cell populations within the parenchyma and meninges of mice with amyloid or tau pathology. | Nature

Extended Data Fig. 4: Characterization of T cell populations within the parenchyma and meninges of mice with amyloid or tau pathology.

From: Microglia-mediated T cell infiltration drives neurodegeneration in tauopathy

Extended Data Fig. 4: Characterization of T cell populations within the parenchyma and meninges of mice with amyloid or tau pathology.The alternative text for this image may have been generated using AI.

(a) Heatmap showing identified marker genes in each of the categorized cell types in Total T cells, CD4+ and CD8+ T cells. (b) Total T cells from brain parenchyma and meninges with TCR assigned into 13 cell types as visualized by UMAP plot. (c) TRAV and TRBV enrichment in CD8+ and CD4+ T cells in TE4 and A/PE4 mice. (d) Representative TCR-TRBV projection in E4, A/PE4 and TE4 mice.

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