Fig. 4: The in vivo efficacy of JNJ-1802 against DENV-1/45AZ5 was examined in NHPs by measuring viral RNA load and IgM/IgG response.
From: Blocking NS3–NS4B interaction inhibits dengue virus in non-human primates
a, Schematic of the DENV-1/45AZ5 study. b, The effect of JNJ-1802 on viral RNA in rhesus macaques (R1–R12) infected with DENV-1/45AZ5 (0.5 ml at 1.2 × 105 PFU per ml) and treated with JNJ-1802 at 6 mg per kg per day once daily (n = 6; right) in comparison to the vehicle-treated group (n = 6; left). Treatment started 3 days before infection. RNA levels are expressed in GCE per ml. Data are mean ± s.d. The LLOQ of 100 GCE per ml is indicated by a dotted line in the graphs. c,d, ELISA data are presented as end-point titres by study day, which is defined as the reciprocal of the highest dilution of the serum that gives a positive signal. Samples were assayed in duplicate. Data are mean. For a, the schematic was adapted from ref. 3, Springer Nature Limited. The dagger symbol indicates the day of euthanasia.
