Extended Data Fig. 6: scHi-C recovers loss of chromosome segregation and chromosomal instability features.
From: Whole-genome doubling drives oncogenic loss of chromatin segregation
a, Chromosome interactions in pseudo-bulk Hi-C data derived from the aggregation of single-cell Hi-C data for RPETP53−/− control and WGD, and Log2 fold-changes between WGD and Control (right) conditions. For individual conditions, interactions are shown as the Pearson correlation of the chromosome level Observed/Expected values for each pair of chromosomes. For WGD/Control condition, control and WGD correlation values were increased by 1 before computing the ratio. b, Fraction of altered genome in RPETP53−/− control, WGD with no LCS, and WGD/LCS single cell groups. p-value calculated by two-tailed Wilcoxon test. Boxplots: central line is the median, bounding box corresponds to the 25th–75th percentiles, and the whiskers extend up to 1.5 times the interquartile range. c, Relative copy number changes in each of the single cells queried by scHi-C. Cells are sorted by fraction of altered genome.
