Extended Data Fig. 11: Examples of compartment repositioning events associated with gene expression and epigenetic changes.
From: Whole-genome doubling drives oncogenic loss of chromatin segregation
a, d, Detailed characterization of histone modification and CTCF changes in the indicated genomic region in RPETP53−/− control and tumour samples. b, e, Detailed characterization of the compartment and histone modification and CTCF changes in the indicated genomic region in RPETP53−/− control and tumour samples. Top: sub-compartment assignments inferred by Calder. Bottom: histone mark intensities c, f, Significant interactions within the indicated regions in RPETP53−/− control and tumour 1 samples. Histone mark intensities for the corresponding sample are shown at the bottom. g,h, Percentage of activating (red, consistent n = 91, inconsistent n = 22) and inactivating (blue, consistent n = 170, inconsistent n = 30) CoREs that were detected by CBS and that could be traced back to compartment changes occurring already in WGD cells.
