Fig. 3: LCS in WGD single cells.
From: Whole-genome doubling drives oncogenic loss of chromatin segregation
a, Interchromosome LCS score calculated for each cell. Black dots indicate WGD cells not exhibiting LCS, red dots indicate WGD cells exhibiting LCS. For the boxplots, the central line is the median, the bounding box corresponds to the 25–75th percentiles and the whiskers extend up to 1.5-times the interquartile range. P value was calculated using two-tailed Wilcoxon test. b, Representative Hi-C maps at 10 Mb resolution of WGD RPE TP53−/− cells with (right) and without LCS (left). Short–short (SS) and long–short (LS) chromosome contacts were compared using two-tailed Wilcoxon test. c, Average interchromosomal interaction rank across single cells for each pair of chromosomes in control and WGD-LCS cells. The chromosome pair (10,X) is highlighted. d, Single-cell compartment segregation score distribution.
