Fig. 6: Copy number alterations and subcompartment repositioning in CP-A TP53−/− soft-agar colonies.
From: Whole-genome doubling drives oncogenic loss of chromatin segregation
a, Timeline of in vitro and soft-agar colony-formation assay for CP-A TP53−/− post-WGD cells. b, Images of crystal violet colony staining and representative images of individual colonies for CP-A TP53−/− clone 3 and clone 19 (n = 3 independent wells). c, Volcano plots of segmented genomic regions, between each colony (col1 and col2) and control cells. P values calculated using DiffComp. d, Compartment rank in control (left), WGD (centre), and colonies (right) for each activating and inactivating CoRE. Lines connect compartment ranks belonging to the same CoRE. e, Overlap between CoREs identified in colonies derived from the same CP-A TP53−/− clone when considering all or only consistent CoREs. Grey bars represent CoREs specific to one of the two colonies, whereas red bars denote common CoREs. f, Schematic representation of loss of chromatin segregation and subcompartment repositioning induced by WGD.
