Extended Data Fig. 10: AlphaFold2 model of OR51E2.
From: Structural basis of odorant recognition by a human odorant receptor
a) AlphaFold2 predicted structure of OR51E2. The pLDDT confidence metric is shown highlighting relatively high confidence in the transmembrane regions and extracellular loops. b) AlphaFold2 predicted structure of unbound OR51E2 (gray) superimposed onto the experimentally determined structure of propionate-bound OR51E2 in the active state (green cartoon and yellow spheres). In the AlphaFold2 model, TM6 is inwardly displaced compared to the active structure. Closeup views of (c) the Connector region and (d) the G protein-coupling region are provided. e) Slice through surface representation of AlphaFold2 predicted OR51E2, suggests solvent accessibility of the ligand binding site in the inactive state.
