Extended Data Fig. 1: Alignment of OR51E2, rhodopsin and β2 adrenergic receptor (β2AR) amino acid sequences as described in part by de March et al.³³ and implemented on GPCRdb7⁵.

Conservation is highlighted from low (white) to high (dark blue) and the consensus amino acid is shown. Transmembrane domains are boxed in yellow. The most conserved residue in class A GPCRs for each transmembrane domain is boxed and labeled in orange. Residues used to align OR and Class A GPCR sequences are highlighted by asterisks, which are colored orange when the residue is common to all Class A GPCRs and black when it is specific to ORs. The most conserved residues used for numbering of the intracellular and extracellular loops are also indicated in italic when available. Generic numbers follow the revised Ballesteros-Weinstein numbering for Class A GPCRs^32,34.