Extended Data Fig. 4: Cryo-EM density and atomic model.
From: Structural basis of odorant recognition by a human odorant receptor
a) Orthogonal views of local resolution for the globally refined map of OR51E2-Gs calculated with the local resolution estimation tool in cryoSPARC. b) Close-up view showing the local resolution of the propionate binding site. c) Representative cryo-EM densities from the 3D reconstruction of OR51E2 from a sharpened, globally refined map of OR51E2-Gs at a map threshold of 0.635. Shown are the transmembrane helices and loop regions of OR51E2 as well as the C-terminal helix of miniGαs. d) Close-up view of cryo-EM density (yellow sticks and density) supporting propionate binding pose using a sharpened map locally refined around only the 7TM domain of OR51E2 at map threshold of 1.0.
