Extended Data Fig. 2: Activation of the Notch receptor pathway.
From: Molecular sensing of mechano- and ligand-dependent adhesion GPCR dissociation
a, Structural layout of the Drosophila Notch receptor protein with its ECR containing numerous epidermal growth factor (EGF) domains, the negative regulatory region (NRR), which physiologically suppresses the staggered proteolytic processing at various cleavage sites (S2–S4) until receptor stimulation, and the ICR with sequences involved in nuclear import of the Notch intracellular domain (NICD) and co-activation of gene transcription. b, Sequence of events that correspond to Notch processing and transmembrane signal transduction and involved proteases31. c, Amino acid sequence and domain and motif annotation of the Cirl-NRS-LexA protein. ADAM, A disintegrin and metalloproteinase; ECR, extracellular region; ICR, intracellular region; TM, transmembrane domain.
