Extended Data Fig. 4: Transcriptomic changes in Syn61∆3 following phage infection.
From: A swapped genetic code prevents viral infections and gene transfer
Volcano plot shows the differential expression between uninfected and REP12-infected Syn61∆3 cells, 40 min post-infection, based on n = 3 independent experiments (Methods). QueG encodes epoxyqueuosine reductase that catalyzes the final step in the de novo synthesis of queuosine in tRNAs. TrmJ encodes tRNA Cm32/Um32 methyltransferase that introduces methyl groups at the 2′-O position of U32 of several tRNAs, including tRNA-SerUGA. Differential expression and -Log10 adjusted p-values were calculated using the DESeq2 algorithm55. Source data is available within this paper.
