Extended Data Fig. 8: Analysis of caspofungin-resistant phenotype and chemical structure of echinocandin drugs.
From: Structural and mechanistic insights into fungal β-1,3-glucan synthase FKS1
a, Analysis of caspofungin-resistant phenotype of S. cerevisiae strain with indicated FKS1 mutations. The concentrations of caspofungin tested are indicated on the top. b, Chemical structure of four types of echinocandin drugs. They all feature a lipid tail as highlighted by the box. c, Chemical structure of the lipid alkyl chains (left panel) and phospholipid (right panel) identified from FKS1 structure.
