Extended Data Fig. 3: Reactivity of sera from paediatric hepatitis cases against human seasonal coronaviruses and SARS-CoV-2.
From: Adeno-associated virus 2 infection in children with non-A–E hepatitis
Sera from the paediatric hepatitis cases were screened for reactivity against spike proteins from a) seasonal coronaviruses 229E, OC43, NL63 and HKU1, and b) SARS-CoV-2 nucleocapsid (N), spike (S), and N-terminal domain (NTD) and receptor binding domain (RBD) of S by electrochemiluminescence (MSD-ECL). Reactivity of the 23 samples (Hepatitis) was compared with 16 sera from contemporaneous control samples from children (Group 4 Controls), and three groups of sera from adults of known SARS-CoV-2 status; Negatives (never tested positive for SARS-CoV-2; n = 30), Vaccinated two doses (n = 28) and Infected (n = 39).
