Extended Data Fig. 1: Continued scope of amines.
From: Enantioconvergent Cu-catalysed N-alkylation of aliphatic amines
Standard reaction conditions: amine (0.20 mmol), racemic alkyl chloride E1 (1.5 equiv.), CuI (10 mol%), L*4 (15 mol%) and Cs2CO3 (3.0 equiv.) in 1,4-dioxane (4.0 ml) under argon at 45 °C. The yields are isolated. The e.e. values are based on chiral high-performance liquid chromatography analysis. The d.r. value is based on crude 1H NMR analysis. aAmine hydrochloride (0.20 mmol) and Cs2CO3 (4.0 equiv.). bL*5 (15 mol%) in N-methyl-2-pyrrolidone/ethyl acetate (2.8 ml/1.2 ml) at r.t. cL*5 (15 mol%) in N-methyl-2-pyrrolidone/ethyl acetate (2.4 ml/1.6 ml) at r.t. dL*2 (15 mol%). eL*4 (15 mol%). fCuBH4(PPh3)2 (10 mol%), L*5 (15 mol%) in N,N-dimethylformamide/cyclohexane (3.2 ml/0.80 ml) at r.t. gAmine dihydrochloride (0.20 mmol) and Cs2CO3 (5.0 equiv.).
